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Look deeper into dedifferentiated liposarcoma (DDLPS).

Look deeper into dedifferentiated liposarcoma (DDLPS)

What do you see when you look deeper?

Soft tissue sarcoma (STS) is a rare and heterogeneous type of tumour with more than 100 different histologic subtypes, and each subtype has a different clinical behaviour.1

  • Liposarcoma (LPS) represents the predominant subtype of STS, comprising 15-20% of all cases2

  • Among liposarcomas, DDLPS represents 15-20% of diagnosed cases2

Estimated proportion of liposarcoma2

STS and DDLPS percentage


MLPS=myxoid/round-cell liposarcoma; PLPS=pleomorphic liposarcoma; WDLPS=well-differentiated liposarcoma.

DDLPS is an aggressive subtype of liposarcoma with a poor prognosis3

Common symptoms of DDLPS4-6

  • A new visible lump that develops under the skin (not usually painful at first)

  • Painful swelling or numbness in the area around the lump

  • Constipation

  • Abdominal pain, cramping, and/or swelling

  • Blood in the stool and/or vomit

  • Cough or breathlessness

Look closer into the DDLPS disease burden

DDLPS Local Recurrence Rate
Metastatic Rate DDLPS
DDLPS Mortality Rate
DDLPS patient

While DDLPS is an aggressive subtype of liposarcoma with poor prognosis, little has changed in the past 5 decades in terms of treatment modalities3,7

To learn more go to the next page.

References:

  1. Gamboa AC, Gronchi A, Cardona K. CA Cancer J Clin. 2020;70(3):200-229.

  2. Schöffski P. Oncol Res Treat. 2022;45(9):525-543.

  3. Gahvari Z, Parkes A. Curr Treat Options Oncol. 2020;21(2):15. doi:10.1007/s11864-020-0705-7

  4. NHS. Soft tissue sarcomas. Accessed 6 March 2024. https://www.nhs.uk/conditions/soft-tissue-sarcoma/

  5. Johns Hopkins Medicine. Sarcoma. Accessed 6 March 2024. https://www.hopkinsmedicine.org/health/conditions-and-diseases/sarcoma

  6. Johns Hopkins Medicine. Liposarcoma. Accessed 6 March 2024. https://www.hopkinsmedicine.org/health/conditions-and-diseases/sarcoma/liposarcoma

  7. Italiano A. Cancer Discov. 2023;13(8):1765-1767.